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Critically, it does NOT activate growth hormone receptors or stimulate IGF-1 signaling, which distinguishes it from full-length human growth hormone (hGH) and theoretically reduces the incidence of systemic growth-promoting effects

In a longitudinal study of healthy women during pregnancy, after correction for hemodilution, plasma MMA concentrations showed a moderate increase throughout pregnancy from 20 weeks gestation (Murphy et al., 2007)